You can use the buttons to give old and homemade picture frames a new look, or if you're into scrapbooking, the buttons can add accent to the page. You can turn your older kids' plain shirts into something colorful and fun by sewing buttons on the shirts...Here's something I saw online - a button bracelet.
I've also seen bracelets made with buttons that dangle down instead of sewn on a band like above. You could also make a brooch with the buttons if it's big enough. Just cut off the shank and glue a pin back to it.